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I think Samurai Jack is the best animation. It would be more appropriate to say that the creator has the best imagination I have ever seen. I am not trying to compare this simple yet brilliant animation to the likes of Final Fantasy or Ghost in the Shell, but the creativity is out of the world, metaphorically & literally. Where most of the animators (graphic artists) try to bring the animation as close to the reality, Samurai Jack goes full blast into making taking the audience into a wonderful fantasy. The variety is so enormous that it just blows my mind. How can a person have such an innocent & vivid imagination? The stories are thought provoking & each one is quite unique in characters & places.
After such an impression, I decided to find some more information about this animation & reached Wikipedia. It turns out it has won Emmy award, 4 times. And surprisingly its an American animation created by Genndy Tartakovsky & that he lived in Chicago [1].
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[1] http://en.wikipedia.org/wiki/Genndy_Tartakovsky